A photochemical method for determining plasma homocysteine with limited sample processing

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A photochemical method for determining plasma homocysteine with limited sample processing.

The photolytic formation of thiyl radicals allows for the selective detection of total homocysteine (tHcy) in plasma after reduction and filtering. The mechanism is based on the reduction of viologens by the α-amino carbon centred radical of Hcy generated by intramolecular hydrogen atom transfer (HAT) of its thiyl radical.

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Clomipramine is a tricyclic antidepressant. Different methods for determination of clomipramine hydrochloride in plasma have been described. Most of these procedures favor the use of acidic back-extraction in extraction procedure and HPLC as the analytical technique. In this study, the clomipramine extraction procedure was modified and a direct injection to the column was performed to shorten t...

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ژورنال

عنوان ژورنال: Chem. Commun.

سال: 2014

ISSN: 1359-7345,1364-548X

DOI: 10.1039/c4cc00432a